Clinical implication of Dendritic Cell Infiltration in Cervical Tuberculous Lymphadenitis. |
Jae Woo Jung, Young Woo Lee, Jae Cheol Choi, Seung Min Yoo, Hwa Yeon Lee, Seoung Young Lim, Jong Wook Shin, Jae Yoel Kim, In Whn Park, Mi Kyung Kim, Byoung Whui Choi |
1Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea. basthma@hanmail.net 2Department of Radiology, College of Medicine, Chung-Ang University, Seoul, Korea. 3Department of Pathology, College of Medicine, Chung-Ang University, Seoul, Korea. 4Department of Internal Medicine, 3Kangbuk Samsung Hospital, Sung Kyun Kwan University, School of Medicine, Seoul, Korea. |
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Abstract |
BACKGROUND Cervical tuberculous lymphadenopathy is a very common disease with a similar incidence to pulmonary tuberculosis. Dendritic cells play a role of initial antigen presentation of this illness. Nevertheless, the precise role of these antigen-presenting cells according to the clinical features in unclear. The aim of this study was to determine the clinical implication of dendritic cell infiltration in the cervical lymph nodes. METHODS: A review of the clinical characteristics was carried out retrospectively based on the clinical records and radiography. Immunohistochemical staining was performed on the available histology specimens of 72 cases using the S-100b polyclonal antibody for dendritic cells. The number of dendritic cells with tuberculous granuloma were determined. A x2 test, unpaired T test and multiple logistic regression analysis were performed. RESULTS: Thirty percent of subjects had previous or concurrent pulmonary TB. Twenty one percent of cases showed a positive reaction on the AFB stain. Within a granuloma, the number of infiltrated dendritic cells was 113.0+/-7.0. The incidence of fever and cough decreased with increasing infiltration of dendritic cells Multivariate regression analysis showed that the infiltration of dendritic cells could significantly contribute to fever. CONCLUSION: Overall, dendritic cells can control a Mycobacterium tuberculosis infection and modulate the immune response, as well as resolve the clinical manifestations of TB lymphadenopathy. |
Key Words:
Tuberculosis, Lymph Node, S-100b, Dendritic Cells |
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