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Tuberc Respir Dis > Volume 60(6); 2006 > Article
Tuberculosis and Respiratory Diseases 2006;60(6):638-644.
DOI:    Published online June 1, 2006.
Association between the Human Surfactant Protein-A(SP-A) Gene Locus and Chronic Obstructive Pulmonary Disease in Korean Population.
Joo Ock Na, , Myung Ho Oh, , Jae Sung Choi, , Ki Hyun Seo, , Yong Hoon Kim,
1Department of Internal Medicine, Soonchunhyang University Collage of Medicine, Cheonan, Korea.
2Department of Pediatrics Soonchunhyang University Collage of Medicine, Cheonan, Korea.
S: This study investigated whether or not a polymorphism in the gene encoding the surfactant protein A(SP-A) has any bearing on the individual susceptibility to the development of chronic obstructive pulmonary disease(COPD) in a genetically homogenous Korean population. METHODS: The genotypes of 19 COPD patients and 20 healthy neonates as controls were tested using a polymerase chain reaction followed by restriction fragment length polymorphism analysis for the SP-A gene. RESULTS: The specific frequencies of the 6A2 and 6A18 alleles of SP-A1 and the 1A2 allele of SP-A2 were much higher in the COPD group than control group (p<0.05). However, the frequencies of the 6A3 and 6A4 alleles of SP-A1 and the 1A0 allele of SP-A2 in the COPD group were significantly lower than the control group. In the COPD group, the frequencies of the +50 locus genotypes GG of SP-A1 and the +9 locus genotypes CC of SP-A2 were 85.0% and 60.6%, respectively, and 19.7% and 24.8% in the control group, respectively. The frequencies of the polymorphic genotypes or alleles showed a statistically significant difference between the COPD group and the control group (P<0.05). CONCLUSION: A genetic polymorphism in SP-A is associated with the development of COPD in the Korean population.
Key Words: Surfactant, SP-A, SP-A alleles, Genotype of SP-A, COPD, Genetic polymorphism

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