Difference in Protein Markers According to the Survival of Sepsis Patients using Protein Chips.

Park, Myoung Ok; Lee, Heui Young; Son, Hee Jung; Sung, Ji Hyun; Lee, Seung Joon; Lee, Sung Joon; Ha, Kwon Soo; Kim, Woo Jin

doi:2006.61.1.41

Tuberc Respir Dis > Volume 61(1); 2006 > Article

Original Article

Tuberculosis and Respiratory Diseases 2006;61(1):41-45.
DOI: https://doi.org/10.4046/trd.2006.61.1.41 Published online July 1, 2006.

Difference in Protein Markers According to the Survival of Sepsis Patients using Protein Chips.

Myoung Ok Park, Heui Young Lee, Hee Jung Son, Ji Hyun Sung, Seung Joon Lee, Sung Joon Lee, Kwon Soo Ha, Woo Jin Kim

¹Department of Internal Medicine, College of Medicine, Kangwon National University, Korea. pulmo2@knuh.or.kr
²Department of Anesthesia, College of Medicine, Kangwon National University, Korea.
³Department of Molecular and Cellular Biochemistry, College of Medicine, Kangwon National University, Korea.

Abstract

BACKGROUND
Several clinical scoring systems are currently being used to predict the outcome of sepsis, but they all have certain limitations. Therefore, we sought to identify the proteomic biomarkers, with wsing proteomic tools, that differed according to the outcome of sepsis patients. METHODS: Upon admission to the ICU, blood samples were obtained from the 16 patients with sepsis who were enrolled in this study. Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) was used to identify the markers that could predict the outcome of sepsis. RESULTS: We found six peaks, by using cation and anion chips, that statistically differed between those patients who died and those who survived. CONCLUSION: The biomarkers we found by using proteomic tools may help predict the prognosis and also plan the treatment of sepsis.

Key Words: Sepsis, Treatment outcome, Proteomics