A Case Report of Disseminated Extranodal Marginal Zone B-Cell Lymphoma of MALT Manifested by Solitary Pulmonary Nodule.

Cho, Joon Hyun; Jung, Jong Pil; Cha, Hee Jeong; Park, Chang Ryul; Kim, Sung Ryul; Kim, Hawk; Park, Jin Woo; Woo, Soon Joo; Eum, Eun A; Lee, Ki Young; Jegal, Yang Jin

doi:2006.61.2.171

Tuberc Respir Dis > Volume 61(2); 2006 > Article

Case Report

Tuberculosis and Respiratory Diseases 2006;61(2):171-177.
DOI: https://doi.org/10.4046/trd.2006.61.2.171 Published online August 1, 2006.

A Case Report of Disseminated Extranodal Marginal Zone B-Cell Lymphoma of MALT Manifested by Solitary Pulmonary Nodule.

Joon Hyun Cho, Jong Pil Jung, Hee Jeong Cha, Chang Ryul Park, Sung Ryul Kim, Hawk Kim, Jin Woo Park, Soon Joo Woo, Eun A Eum, Ki Young Lee, Yang Jin Jegal

¹Department of Internal Medicine, Ulsan University Hospital, Korea. yjjegal@uuh.ulsan.kr
²Department of Thoracic and Cardiovascular Surgery, Ulsan University Hospital, Korea.
³Department of Pathology, Ulsan University Hospital, Korea.
⁴Department of Laboratory Medicine, Ulsan University Hospital, Korea.

Abstract

Extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) is usually indolent. Although it was reported recently that about 20-30% cases of MALT lymphoma presented with a disseminated disease at diagnosis, it was described as a disease localized at diagnosis and remaining stable for a prolonged period. However, only a few cases of MALT lymphoma involved the lung and gastrointestinal tract all at once. We report a case of a 73-year-old man with disseminated MALT lymphoma. He presented with non-productive cough, initial chest radiograph showed a nodule in the right lower lobe. The diagnosis of stage IV MALT lymphoma was made by CT scan, video-assisted thoracoscopic excisional biopy, gastrofiberscopic biopsy and bone marrow biopsy. The lymphoma involved the lung, stomach and bone marrow at the time of diagnosis. Because he refused chemotherapy, he discharged after Helicobacter pylori eradication without chemotherapy. Regular follow-up examination did not show any evidence of disease progression over 22 months.

Key Words: Extranodal marginal zone B-cell lymphoma of MALT, Disseminated, Solitary pulmonary nodule