A Case of Diffuse Infiltrative Lymphocytosis Syndrome Associated with Human Immunodeficiency Virus Infection.

Kwon, Sun Ok; Park, Won Wo; Lee, Hyun Kyung; Lee, Sung Soon; Kang, Youn Kyung; Lee, Young Min; Lee, Hyuk Pyo; Kim, Joo In; Choi, Soo Jeon; Yum, Ho Kee

doi:2006.61.3.289

Tuberc Respir Dis > Volume 61(3); 2006 > Article

Case Report

Tuberculosis and Respiratory Diseases 2006;61(3):289-293.
DOI: https://doi.org/10.4046/trd.2006.61.3.289 Published online September 1, 2006.

A Case of Diffuse Infiltrative Lymphocytosis Syndrome Associated with Human Immunodeficiency Virus Infection.

Sun Ok Kwon, Won Wo Park, Hyun Kyung Lee, Sung Soon Lee, Youn Kyung Kang, Young Min Lee, Hyuk Pyo Lee, Joo In Kim, Soo Jeon Choi, Ho Kee Yum

¹Department of Pathology, Seoul Paik Hospital, Inje University, Korea. pulho@korea.com
²Department of Internal Medicine, Seoul Paik Hospital, Inje University, Korea.

Abstract

Diffuse infiltrative lymphocytosis syndrome is an autoimmune syndrome that is characterized by the oligoclonal expansion of CD8+ T-lymphocytes in response to human immunodeficiency virus (HIV) antigens. The clinical manifestations include bilateral enlargement of the parotid glands, lymphocytic interstitial pneumonitis, lymphocytic hepatitis, neurological involvement and systemic lymphadenopathies. In addition to a positive HIV test, the diagnostic histopathological findings are CD8+ T-lymphocytic infiltrations in the lymphnodes, liver, lung, muscle and the salivary or lacrimal glands without granulomatous or neoplastic involvement. We report a case of pulmonary involvement of diffuse infiltrative lymphocytosis syndrome that was associated with a human immunodeficiency virus infection.

Key Words: Diffuse infiltrative lymphocytosis syndrome, HIV, CD8+