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Tuberc Respir Dis > Volume 61(6); 2006 > Article
Tuberculosis and Respiratory Diseases 2006;61(6):547-553.
DOI: https://doi.org/10.4046/trd.2006.61.6.547    Published online December 1, 2006.
Comparison of Thinprep (Liquid-Based Cytology) and Conventional Cytology: Abnormal Lesion on Bronchoscopy.
Jung Ho Lee, , Jung Kyung Yang, , In Bum Jung, , Jung Hea Lee, , Hae Jung Sul, , Yoon Mi Kim, , Bum Kyeng Kim, , Yue Jin Choi, , Moon Joon Na, , Ji Woong Son,
1Department of Internal Medicine, College of Medicine, Konyang University, Daejeon, Korea. sk1609@hanmail.net
2Department of Pathology, College of Medicine, Konyang University, Daejeon, Korea.
Abstract
BACKGROUND
Liquid-based cytology is currently known as an effective method, and cervical cytology has been shown to be especially effective from of malignancy detection. In our study, the cytological detection rates of the Thinprep (Liquid-based cytology) and conventional cytology (bronchial washing & brushing) for endobronchial lesions were compared. METHODS: Between July 2005 and September 2005, the data from 30 patients with respiration symptom, who had shown abnormal lesion on bronchoscopy, were collected. RESULTS: The bronchoscopic biopsy group was consisted of 30 cytodiagnosis specimens, 24 of which were confirmed to be malignant. The others were tuberculosis (4), bronchiectasis and bronchopulmonary fistula (1 each). Of the 24 malignant case, cancer or atypical cells were detected in 19, 17 and 12 of the Thinprep, brushing cytology and washing cytology cases, respectively. None one of the methods detected cancer cells in the non-malignant specimens. Washing cytology has shown sensitivity, specificity, and positive and negative predictive values of 50, 100, 100 and 33.3% respectively. Brushing cytology has shown sensitivity, specificity, and positive and negative predictive values of 70.8, 100, 100 and 46.2%, respectively. Thinprep has shown sensitivity, specificity, and positive and negative predictive values of 79.2, 100, 100 and 54%, respectively. CONCLUSIONS: Thinprep (liquid-based cytology) showed better sensitivity and negative predictive values for the evaluation of lung cancer than conventional cytology. However a large-scale study will be needed in the future.
Key Words: Thinprep, Conventional cytology, Bronchoscopy, Respiration cytology


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