Tuberc Respir Dis > Volume 62(5); 2007 > Article
Tuberculosis and Respiratory Diseases 2007;62(5):382-388.
DOI:    Published online May 1, 2007.
Cognitive Dysfunction in non-hypoxemic COPD Patients.
Woo Jin Kim, Seon Sook Han, Myoung Ok Park, Seung Joon Lee, Seong Jae Kim, Jung Hie Lee
1Department of Internal Medicine, College of Medicine, Kangwon National University, Chuncheon, Korea.
2Department of Psychiatry, College of Medicine, Kangwon National University, Chuncheon, Korea.
The cognitive function is impaired in patients with hypoxemic chronic obstructive pulmonary disease (COPD). However, there are conflicting results regarding the cognitive function in patients with non-hypoxemic COPD. COPD patients also have sleep disorders. This study examined the cognitive function in non-hypoxemic COPD patients, and nocturnal sleep was assessed in COPD patients with a cognitive dysfunction. METHODS: Twenty-eight COPD patients (mean age, 70.7 years) with an oxygen saturation > 90%, and 33 healthy control subjects (mean age, 69.5 years) who had visited for a routine check-up were selected. The neurocognitive tests were performed using the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K) Neuropsychological Battery. RESULTS: The scores of the word list recall test (p=0.03) and the word list recognition test (p=0.006) in the COPD group were significantly lower than those in the control group. Nine patients showed a significantly impaired cognitive function. Seven of these underwent polysomnography, which revealed apnea-hypopnea indices > or = five per hour in five patients. The median oxygen desaturation index and median limb movement index were 3.6/h and 38.6/h, respectively. CONCLUSION: These results suggest that the verbal memory function is impaired in non-hypoxemic COPD patients. Six out of seven COPD patients with an impaired cognitive function had sleep disorders of sleep apnea and/or periodic limb movements during sleep.
Key Words: Chronic obstructive pulmonary disease, Cognitive function, Sleep disorders
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