A Case of Multiple Micronodular Pneumocyte Hyperplasia of the Lung in a Man with Tuberous Sclerosis.

Nam, Dong Hyuk; Choi, Yoon Jung; Lee, Ju Hyun; Na, Hyoung Jung; Kim, Dong Hwan; Kim, Chong Ju; Lee, Sun Min; Hong, Yong Kug; Han, Chang Hoon

doi:2008.64.5.369

Tuberc Respir Dis > Volume 64(5); 2008 > Article

Case Report

Tuberculosis and Respiratory Diseases 2008;64(5):369-373.
DOI: https://doi.org/10.4046/trd.2008.64.5.369 Published online May 1, 2008.

A Case of Multiple Micronodular Pneumocyte Hyperplasia of the Lung in a Man with Tuberous Sclerosis.

Dong Hyuk Nam, Yoon Jung Choi, Ju Hyun Lee, Hyoung Jung Na, Dong Hwan Kim, Chong Ju Kim, Sun Min Lee, Yong Kug Hong, Chang Hoon Han

¹Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea. hch7001@nhimc.or.kr
²Department of Pathology, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea.
³Department of Radiology, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea.

Abstract

Tuberous sclerosis (TS) is an autosomal dominant disorder that is characterized by cutaneous lesions, seizures, mental retardation and hamartomas in various organs including the skin, kidney and brain. Pulmonary involvement is extremely rare, and occurs in approximately 0.1 to 1% of TS cases. Recent reports have indicated multiple micronodular pneumocyte hyperplasia (MMPH) as another rare form of pulmonary involvement of tuberous sclerosis. We report a case of a 35 year-old-male patient who had no pulmonary symptoms but showed multinodular pulmonary shadows on his chest CT scan. The patient was finally diagnosed with TS with MMPH of the lung. MMPH does not appear to have any malignant potential but the clinical significance of MMPH in TS patients is unknown.(Tuberc Respir Dis 2008;64:369-373)

Key Words: Tuberous sclerosis, Multiple micronodular pneumocyte hyperplasia