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Tuberc Respir Dis > Volume 64(6); 2008 > Article
Tuberculosis and Respiratory Diseases 2008;64(6):422-426.
DOI: https://doi.org/10.4046/trd.2008.64.6.422    Published online June 1, 2008.
Detection of Clarithromycin-resistant Strains from Clinical Isolates of Mycobacterium abscessus.
Seung Heon Lee, , Young Kil Park, , Sung Weon Ryo, , Myung Sup Shim, , Woo Jin Lew, , Hee Jin Kim,
Korean Institute of Tuberculosis, Seoul, Korea. hatchingbird@yahoo.co.kr
Abstract
BACKGROUND
Mycobacterium abscessus is the most pathogenic and drug-resistant rapid-growing mycobacterium. Clarithromycin or azithromycin are the only regular oral antimycobacterial agents that have an effect on M. abscessus. We tried to detect the clarithromycin-resistant strains from the clinical isolates of M. abscessus. METHODS: We tried to isolate the clarithromycin-resistant strains from 220 clinical isolates of M. abscessus by performing using reverse hybridization assay (RHA) and the broth microdilution test (BMT). RESULTS: Seven resistant strains (3.2%) from all the tested clinical isolates were detected by BMT. Three of these resistant strains were also detected by RHA and it was confirmed that they had point mutants. CONCLUSION: These results showed that clarithromycin resistance in M. abscessus clinical isolates is related to a point mutation and other unknown mechanisms.
Key Words: Mycobacterium abscessus, Reverse hybridization assay, Broth microdilution test, 23S rRNA, Clarithromycin


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