Tuberc Respir Dis > Volume 64(6); 2008 > Article
Tuberculosis and Respiratory Diseases 2008;64(6):466-470.
DOI:    Published online June 1, 2008.
A Case of Pulmonary Embolism in a Patient with a Factor VII Gene Promoter -401G/A Polymorphism.
Bo Ram Min, Shin Kim, Ji Hae Park, Jin Nyeong Chae, Won Il Choi
1Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.
2Department of Immunology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.
A factor VII gene -401 G/A polymorphism was identified in a patient with a pulmonary embolism. The patient was a 71-year-old woman who presented with acute-onset dyspnea. A chest CT scan revealed a pulmonary embolism. Despite the administration of low-dose warfarin as anticoagulation therapy, there was an excessively prolonged prothrombin time (PT). The blood tests revealed lower factor VII activity than normal. Full factor VII gene sequencing revealed a G to A substitution at ?401 in the promoter region. There were no other gene sequence anomalies. PCR-based analysis indicated lower factor VII gene expression in the patient than in a control subject. The data suggested the promoter polymorphism to be responsible for the lower transcription level. In conclusion, we encountered a case of Factor VII DNA polymorphism in a patient with a pulmonary embolism showing significantly reduced Factor VII activity.
Key Words: Factor VII, Pulmonary embolism, Genetic polymorphism

Article category

Browse all articles >


Browse all articles >

Editorial Office
101-605, 58, Banpo-daero, Seocho-gu (Seocho-dong, Seocho Art-Xi), Seoul 06652, Korea
Tel: +82-2-575-3825, +82-2-576-5347    Fax: +82-2-572-6683    E-mail:                

Copyright © 2023 by The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

Developed in M2PI

Close layer
prev next