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Tuberc Respir Dis > Volume 65(2); 2008 > Article
Tuberculosis and Respiratory Diseases 2008;65(2):142-146.
DOI: https://doi.org/10.4046/trd.2008.65.2.142    Published online August 1, 2008.
Acute Respiratory Distress Syndrome after Topotecan Therapy in a Patient with Small Cell Lung Cancer.
Jung Hyun Tae, , Jin Hwa Lee, , Yoon Kyung Kim, , Yun Su Sim, , Kyung Jong Lee, , Young Wook Noh, , Jae Jung Park, , Yon Ju Ryu, , Eun Mi Chun, , Jung Hyun Chang,
1Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea. jinhwalee@ewha.ac.kr
2Department of Radiology, Ewha Womans University School of Medicine, Seoul, Korea.
Abstract
Small cell lung cancer is characterized by an aggressive clinical course and a high tendency for early dissemination in spite of a good chemotherapy response. Topotecan is a topoisomerase I inhibitor, and it is used as second-line treatment for small cell lung cancer. The reported dose-limiting adverse reactions to topotecan are mainly hematologic. Yet pulmonary toxicity associated with topotecan is known to be rare. We report here on a case that showed the development of acute respiratory distress syndrome during the 3rd cycle of topotecan chemotherapy in a patient with small cell lung cancer. He developed dyspnea and respiratory failure, and the chest CT scan revealed diffuse ground-glass opacity that was probably due to chemotherapy-related pulmonary toxicity. He finally died of acute respiratory distress syndrome.
Key Words: Small cell carcinoma, Topotecan, Acute respiratory distress syndrome


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