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Original Article
Asthma, Environmental and Occupational Lung Disease
Impact of Microplastic Exposure on Airway Inflammation in an Acute Asthma Murine Model
Joon Young Choi, Jung Hur, Yong Suk Jo, et al.
Tuberc Respir Dis. 2026;89(1):29-37.   Published online October 23, 2025
Background: Widely distributed in the environment, microplastics (MPs) are increasingly recognized as potential respiratory hazards. While several studies suggest their role in worsening allergic airway diseases, findings remain inconsistent. This study aimed to investigate the immunologic effects of repeated MP exposure in an acute murine model of ovalbumin (OVA)-induced asthma. Methods: Female BALB/c mice were assigned to four groups: control with...
Original Article
Asthma, Pulmonary Infection
T-Cell Immune Dysfunction and Progression to Severe COVID-19 in Asthma Revealed by Single-Cell RNA Sequencing
Bo-Guen Kim, Youlim Kim, Sang Hoon Lee, et al.
Tuberc Respir Dis. 2026;89(1):38-54.   Published online November 18, 2025
Background: Little information is available on the immune signaling pathway that drives severe coronavirus disease 2019 (COVID-19) in asthma. Our study uses single-cell RNA sequencing (scRNA-seq) to evaluate the association between immune dysfunction and progression to severe COVID-19 in asthma. Methods: Four patients with asthma and eight patients without asthma from three centers in South Korea were analyzed. Samples were collected...
Original Article
COPD
OM-85 and Respiratory Symptoms in Korean Chronic Obstructive Pulmonary Disease: A Multicenter Observational Study
Chang-Seok Yoon, Tae-Ok Kim, Hong-Joon Shin, et al.
Tuberc Respir Dis. 2026;89(1):55-64.   Published online September 4, 2025
Background Although OM-85 may lessen respiratory symptoms and reduce acute exacerbations in chronic obstructive pulmonary disease (COPD), proof of its overall effectiveness remains incomplete. Methods This prospective, observational, single-arm study was conducted at four university hospitals in South Korea from June 2022 to December 2023. Adults with spirometry-confirmed COPD who were prescribed OM-85 were enrolled, and followed for 6 months (3-months treatment, 3-months...
Original Article
COPD
Risk Factors for Progression to Frequent Exacerbators in Stable Patients with Chronic Obstructive Pulmonary Disease
Sang Hyuk Kim, Hye Yun Park, Hyun Lee, et al.
Tuberc Respir Dis. 2026;89(1):65-74.   Published online September 8, 2025
Background: Little is known about the transition to frequent exacerbators in stabilized patients with chronic obstructive pulmonary disease (COPD). Methods: This study utilized data obtained from the Korean COPD Subgroup Study cohort (KOCOSS), including 511 infrequent exacerbators. The outcome for these groups was progression to frequent exacerbators. Multivariable logistic regression analysis was used to investigate the risk factors for progression. Results: Within...
Original Article
COPD
Clinical Characteristics of Individuals with Chronic Obstructive Pulmonary Disease (COPD), Pre-COPD, Smokers with Normal Lung Function in Korea: Updated Analysis of the Korea COPD Subgroup Study Cohort
Jong Geol Jang, Youlim Kim, Jung-Kyu Lee, et al.
Tuberc Respir Dis. 2026;89(1):75-85.   Published online September 10, 2025
Background: Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung disease characterized by persistent airflow limitation and is a leading cause of mortality worldwide. Pre-COPD refers to a pre-disease state associated with an increased risk of COPD development. This study aims to evaluate the clinical characteristics of individuals with COPD, pre-COPD, and smokers with normal lung function in South Korea,...
Original Article
Tuberculosis
Protocol of a Nationwide Observational Cohort Study for Long-Term Impacts on Lung Health and Life after Tuberculosis in Korea (LIFE-TB)
Chiwook Chung, Jinsoo Min, Doosoo Jeon, et al.
Tuberc Respir Dis. 2026;89(1):86-93.   Published online October 15, 2025
Background: Growing concern has emerged regarding the disease burden and longterm outcomes associated with post-tuberculosis lung disease (PTLD). This study is designed to assess the long-term effects of tuberculosis (TB) on lung health and quality of life, aiming to fill the critical evidence gap in PTLD research. Methods: This investigation utilizes a nationwide, prospective, multicenter observational cohort design. Seven tertiary healthcare...
Original Article
Miscellaneous
Effects of Forceful Breathing Maneuvers of Spirometry on Respiratory Impedance Measured by Oscillometry
Sajal De
Tuberc Respir Dis. 2026;89(1):94-101.   Published online November 19, 2025
Background: Deep inspiratory maneuvers can modify airway diameter, leading to shortterm fluctuations in respiratory impedance (Zrs). However, the impact of the forceful breathing maneuvers used in spirometry on Zrs has not been systematically investigated. This study was designed to assess and compare the effects of spirometry maneuvers on Zrs, as measured by oscillometry, in adult patients with obstructive airway diseases...
Original Article
Miscellaneous
Spirometry-Defined Restriction Modifies the Association between Forced Vital Capacity and Bronchiectasis Exacerbation
Jang Ho Lee, Hyun Lee, Seonok Kim, et al.
Tuberc Respir Dis. 2026;89(1):102-113.   Published online November 6, 2025
Background: Obstructive ventilatory defect (OVD) is the most common ventilatory pattern in bronchiectasis, with low forced expiratory volume in 1 second (FEV1), which is a well-known risk factor for acute exacerbation (AE). However, the impact of spirometry- defined restrictive components (restrictive ventilatory defects [RVD] or mixed ventilatory defects [MVD]) on AE remains unreported. This study evaluated the association between spirometry-defined...
Current Issue
Volume 89(1); Jan 2026
Reviews
Asthma
4973
Biologic Therapies in Severe Asthma and Eosinophilic Granulomatosis with Polyangiitis: Targeted Therapy and Personalized Care
Sang Hyuk Kim
Tuberc Respir Dis. 2026;89(1):1-9.   Published online October 15, 2025
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Critical Care Medicine
Redefining Acute Respiratory Distress Syndrome: A New Clinical Perspective
Si Mong Yoon, Yeon Joo Lee
Tuberc Respir Dis. 2026;89(1):10-17.   Published online October 23, 2025
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Pulmonary Infection
4980
Expert Consensus Statement on the Disease Burden and Vaccination for Respiratory Syncytial Virus Infection in Adults
Joon Young Choi, Chin Kook Rhee, Yong-Il Hwang, Ji-Yong Moon, Kwang Ha Yoo, Hyoung Kyu Yoon
Tuberc Respir Dis. 2026;89(1):18-28.   Published online November 19, 2025
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Original Articles
Asthma, Environmental and Occupational Lung Disease
4975
Impact of Microplastic Exposure on Airway Inflammation in an Acute Asthma Murine Model
Joon Young Choi, Jung Hur, Yong Suk Jo, Chin Kook Rhee
Tuberc Respir Dis. 2026;89(1):29-37.   Published online October 23, 2025
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Asthma, Pulmonary Infection
4978
T-Cell Immune Dysfunction and Progression to Severe COVID-19 in Asthma Revealed by Single-Cell RNA Sequencing
Bo-Guen Kim, Youlim Kim, Sang Hoon Lee, Siyoung Lee, Minjun Choi, Byeongchan Lee, Jae Seok Jeong, Sang-Heon Kim, Hyun Lee, Kwang Ha Yoo
Tuberc Respir Dis. 2026;89(1):38-54.   Published online November 18, 2025
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COPD
OM-85 and Respiratory Symptoms in Korean Chronic Obstructive Pulmonary Disease: A Multicenter Observational Study
Chang-Seok Yoon, Tae-Ok Kim, Hong-Joon Shin, Hak-Ryul Kim, Ki-Eun Hwang, Sung Ho Yoon, Seoung Ju Park, Yong-Soo Kwon
Tuberc Respir Dis. 2026;89(1):55-64.   Published online September 4, 2025
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4969
Risk Factors for Progression to Frequent Exacerbators in Stable Patients with Chronic Obstructive Pulmonary Disease
Sang Hyuk Kim, Hye Yun Park, Hyun Lee, Hyewon Seo, Ji-Hyun Lee, Hyeon-Kyoung Koo, Na Young Kim, Kwang Ha Yoo, Ju Ock Na, Youlim Kim
Tuberc Respir Dis. 2026;89(1):65-74.   Published online September 8, 2025
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4971
Tuberc Respir Dis. 2026;89(1):75-85.   Published online September 10, 2025
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Tuberculosis
Protocol of a Nationwide Observational Cohort Study for Long-Term Impacts on Lung Health and Life after Tuberculosis in Korea (LIFE-TB)
Chiwook Chung, Jinsoo Min, Doosoo Jeon, Yong-Soo Kwon, Jeongha Mok, Hyung Woo Kim, Youngmok Park, Young Ae Kang
Tuberc Respir Dis. 2026;89(1):86-93.   Published online October 15, 2025
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Miscellaneous
4979
Effects of Forceful Breathing Maneuvers of Spirometry on Respiratory Impedance Measured by Oscillometry
Sajal De
Tuberc Respir Dis. 2026;89(1):94-101.   Published online November 19, 2025
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4977
Spirometry-Defined Restriction Modifies the Association between Forced Vital Capacity and Bronchiectasis Exacerbation
Jang Ho Lee, Hyun Lee, Seonok Kim, Bumhee Yang, Hayoung Choi, Chin Kook Rhee, Yong Bum Park, Yeon-Mok Oh, Seung Won Ra
Tuberc Respir Dis. 2026;89(1):102-113.   Published online November 6, 2025
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Letter to the Editor
Pulmonary Infection
Tropheryma whipplei: An Underestimated Pathogen Associated with Pulmonary Infections?
Jingjing Jiang, Haimin Wang, Haijian Zhou, Hai Jiang, Wei Liu, Wenguo Jiang, Mingfang Xu, Kun Li
Tuberc Respir Dis. 2026;89(1):114-116.   Published online October 28, 2025
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Image of Interest
Pulmonary Infection
Aspergilloma Presenting as Endobronchial Mass
Ali Chour, David Laville, Benjamin Chappuy, Nicolas Marc
Tuberc Respir Dis. 2026;89(1):117-119.   Published online September 10, 2025
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Tuberculosis and
Respiratory Diseases

Print ISSN: 1738-3536
Online ISSN: 2005-6184

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