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Original Article
Asthma, Environmental and Occupational Lung Disease
Impact of Microplastic Exposure on Airway Inflammation in an Acute Asthma Murine Model
Joon Young Choi, Jung Hur, Yong Suk Jo, et al.
Tuberc Respir Dis. 2026;89(1):29-37.   Published online October 23, 2025
Background: Widely distributed in the environment, microplastics (MPs) are increasingly recognized as potential respiratory hazards. While several studies suggest their role in worsening allergic airway diseases, findings remain inconsistent. This study aimed to investigate the immunologic effects of repeated MP exposure in an acute murine model of ovalbumin (OVA)-induced asthma. Methods: Female BALB/c mice were assigned to four groups: control with...
Original Article
Asthma, Pulmonary Infection
T-Cell Immune Dysfunction and Progression to Severe COVID-19 in Asthma Revealed by Single-Cell RNA Sequencing
Bo-Guen Kim, Youlim Kim, Sang Hoon Lee, et al.
Tuberc Respir Dis. 2026;89(1):38-54.   Published online November 18, 2025
Background: Little information is available on the immune signaling pathway that drives severe coronavirus disease 2019 (COVID-19) in asthma. Our study uses single-cell RNA sequencing (scRNA-seq) to evaluate the association between immune dysfunction and progression to severe COVID-19 in asthma. Methods: Four patients with asthma and eight patients without asthma from three centers in South Korea were analyzed. Samples were collected...
Original Article
COPD
OM-85 and Respiratory Symptoms in Korean Chronic Obstructive Pulmonary Disease: A Multicenter Observational Study
Chang-Seok Yoon, Tae-Ok Kim, Hong-Joon Shin, et al.
Tuberc Respir Dis. 2026;89(1):55-64.   Published online September 4, 2025
Background Although OM-85 may lessen respiratory symptoms and reduce acute exacerbations in chronic obstructive pulmonary disease (COPD), proof of its overall effectiveness remains incomplete. Methods This prospective, observational, single-arm study was conducted at four university hospitals in South Korea from June 2022 to December 2023. Adults with spirometry-confirmed COPD who were prescribed OM-85 were enrolled, and followed for 6 months (3-months treatment, 3-months...
Original Article
COPD
Risk Factors for Progression to Frequent Exacerbators in Stable Patients with Chronic Obstructive Pulmonary Disease
Sang Hyuk Kim, Hye Yun Park, Hyun Lee, et al.
Tuberc Respir Dis. 2026;89(1):65-74.   Published online September 8, 2025
Background: Little is known about the transition to frequent exacerbators in stabilized patients with chronic obstructive pulmonary disease (COPD). Methods: This study utilized data obtained from the Korean COPD Subgroup Study cohort (KOCOSS), including 511 infrequent exacerbators. The outcome for these groups was progression to frequent exacerbators. Multivariable logistic regression analysis was used to investigate the risk factors for progression. Results: Within...
Original Article
COPD
Clinical Characteristics of Individuals with Chronic Obstructive Pulmonary Disease (COPD), Pre-COPD, Smokers with Normal Lung Function in Korea: Updated Analysis of the Korea COPD Subgroup Study Cohort
Jong Geol Jang, Youlim Kim, Jung-Kyu Lee, et al.
Tuberc Respir Dis. 2026;89(1):75-85.   Published online September 10, 2025
Background: Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung disease characterized by persistent airflow limitation and is a leading cause of mortality worldwide. Pre-COPD refers to a pre-disease state associated with an increased risk of COPD development. This study aims to evaluate the clinical characteristics of individuals with COPD, pre-COPD, and smokers with normal lung function in South Korea,...
Original Article
Tuberculosis
Protocol of a Nationwide Observational Cohort Study for Long-Term Impacts on Lung Health and Life after Tuberculosis in Korea (LIFE-TB)
Chiwook Chung, Jinsoo Min, Doosoo Jeon, et al.
Tuberc Respir Dis. 2026;89(1):86-93.   Published online October 15, 2025
Background: Growing concern has emerged regarding the disease burden and longterm outcomes associated with post-tuberculosis lung disease (PTLD). This study is designed to assess the long-term effects of tuberculosis (TB) on lung health and quality of life, aiming to fill the critical evidence gap in PTLD research. Methods: This investigation utilizes a nationwide, prospective, multicenter observational cohort design. Seven tertiary healthcare...
Original Article
Miscellaneous
Effects of Forceful Breathing Maneuvers of Spirometry on Respiratory Impedance Measured by Oscillometry
Sajal De
Tuberc Respir Dis. 2026;89(1):94-101.   Published online November 19, 2025
Background: Deep inspiratory maneuvers can modify airway diameter, leading to shortterm fluctuations in respiratory impedance (Zrs). However, the impact of the forceful breathing maneuvers used in spirometry on Zrs has not been systematically investigated. This study was designed to assess and compare the effects of spirometry maneuvers on Zrs, as measured by oscillometry, in adult patients with obstructive airway diseases...
Original Article
Miscellaneous
Spirometry-Defined Restriction Modifies the Association between Forced Vital Capacity and Bronchiectasis Exacerbation
Jang Ho Lee, Hyun Lee, Seonok Kim, et al.
Tuberc Respir Dis. 2026;89(1):102-113.   Published online November 6, 2025
Background: Obstructive ventilatory defect (OVD) is the most common ventilatory pattern in bronchiectasis, with low forced expiratory volume in 1 second (FEV1), which is a well-known risk factor for acute exacerbation (AE). However, the impact of spirometry- defined restrictive components (restrictive ventilatory defects [RVD] or mixed ventilatory defects [MVD]) on AE remains unreported. This study evaluated the association between spirometry-defined...
Current Issue
Volume 89(1); Jan 2026
Original Articles
Addressing Low Physical Activity in Chronic Obstructive Pulmonary Disease: The Importance of Patients’ Symptom Perception
Sungmin Zo, Danbee Kang, Sung A Kong, Sun Hye Shin, Jiseon Lee, Jong Geol Do, Hye Yun Park
Received July 29, 2025   Accepted December 3, 2025   Published online December 16, 2025   
DOI: https://doi.org/10.4046/trd.2025.0121    [Epub ahead of print]
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Reviews
Objective Assessment of the Cough: Listening to the Patient’s Voice. A Narrative Review
Tai Joon An
Received October 8, 2025   Accepted December 6, 2025   Published online December 9, 2025   
DOI: https://doi.org/10.4046/trd.2025.0164    [Epub ahead of print]
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Original Articles
Consensus of Korean Asthma Study Group on Definition of Clinical Remission in Severe Asthma: A Modified Delphi Study
Sun Hye Shin, Joon Young Choi, Junghee Yoon, Youlim Kim, Jong Geol Jang, Ji-Yong Moon, Chin Kook Rhee, Kyung Hoon Min, Yong Il Hwang, Yeon-Mok Oh, Seong Yong Lim
Received September 29, 2025   Accepted December 6, 2025   Published online December 9, 2025   
DOI: https://doi.org/10.4046/trd.2025.0161    [Epub ahead of print]
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Dry Medical Thoracoscopy with Artificial Pneumothorax Induction: A Scoping Review
Nai-Chien Huan, Larry Ellee Nyanti, Emilia Sheau Yuin Toh, Kong Meng Tung, Fui Bee Woo, Vikneshwara Shanmugam, Sarvin Vignesh, Y. C. Gary Lee
Received September 4, 2025   Accepted December 8, 2025   Published online December 9, 2025   
DOI: https://doi.org/10.4046/trd.2025.0149    [Epub ahead of print]
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Trends and Sociodemographic Characteristics of Nontuberculous Mycobacterial Infections in South Korea: A Nationwide NHIS-Based Study (2010−2022)
Jeong Mi Seo, Sungchan Kang, Taeyoon Lim, So-mi Shin, Jake Whang, Jinsoo Ko, Gyeong In Lee
Received July 30, 2025   Accepted December 3, 2025   Published online December 9, 2025   
DOI: https://doi.org/10.4046/trd.2025.0127    [Epub ahead of print]
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Cough Assessment in Chronic Respiratory Diseases (COASESS): Findings from a Prospective Multicenter Cross-Sectional Study
Tai Joon An, Hyeon-Kyoung Koo, Chin Kook Rhee, Yee Hyung Kim, Sung-Kyoung Kim, Kyung Hoon Min, Deog Kyeom Kim, Jong-Wook Shin, Hyoung Kyu Yoon, Woo-Jung Song, Jin Woo Kim, Ji-Yong Moon
Received June 19, 2025   Accepted December 6, 2025   Published online December 9, 2025   
DOI: https://doi.org/10.4046/trd.2025.0104    [Epub ahead of print]
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Clinical Outcome Prediction by High-Resolution Computed Tomography and Echocardiography Assessment of Pulmonary Hypertension in Patients with Bronchiectasis
Inhan Lee, Joon-Sung Joh, Ji Yeon Lee, Joohae Kim, Sooim Sin, Hyeon-Kyoung Koo, Ina Jeong
Received April 9, 2025   Accepted December 3, 2025   Published online December 9, 2025   
DOI: https://doi.org/10.4046/trd.2025.0067    [Epub ahead of print]
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Tuberculosis and
Respiratory Diseases

Print ISSN: 1738-3536
Online ISSN: 2005-6184

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