Tuberculosis and Respiratory Diseases

Original Article

COPD

Low Skeletal Muscle Mass and Clinical Outcomes in Chronic Obstructive Pulmonary Disease

Yong Jun Choi, Hye Jung Park, Jae Hwa Cho, et al.

Tuberc Respir Dis. 2023;86(4):272-283. Published online August 11, 2023

Background: In patients with chronic obstructive pulmonary disease (COPD), decreased muscle mass is a frequently encountered comorbidity in clinical practice. However, the evaluation of muscle mass in patients with COPD in real-world practice is rare. Methods: We retrospectively reviewed the electronic medical records of all patients with COPD who underwent bioelectrical impedance analysis at least once between January 2011 and December...

DOI: https://doi.org/10.4046/trd.2023.0008

Original Article

Lung Cancer

Determinants of Willingness to Undergo Lung Cancer Screening among High-Risk Current and Ex-smokers in Sabah, Malaysia: A Cross-Sectional Pilot Study

Larry Ellee Nyanti, Chia Zhen Chua, Han Chuan Loo, et al.

Tuberc Respir Dis. 2023;86(4):284-293. Published online August 29, 2023

Background: Attitudes towards smoking, lung cancer screening, and perceived risk of lung cancer have not been widely studied in Malaysia. The primary objective of this study was to describe the factors affecting the willingness of high-risk current smokers and ex-smokers to undergo low-dose computed tomography (LDCT) screening for lung cancer. Methods: A prospective, cross-sectional questionnaire study was conducted in current smokers...

DOI: https://doi.org/10.4046/trd.2023.0051

Original Article

Lung Cancer

Subtype-Based Microbial Analysis in Non-small Cell Lung Cancer

Hye Jin Jang, Eunkyung Lee, Young-Jae Cho, et al.

Tuberc Respir Dis. 2023;86(4):294-303. Published online June 22, 2023

Background: The human lung serves as a niche for a unique and dynamic bacterial community related to the development and aggravation of multiple respiratory diseases. Therefore, identifying the microbiome status is crucial to maintaining the microecological balance and maximizing the therapeutic effect on lung diseases. Therefore, we investigated the histological type-based differences in the lung microbiomes of patients with lung...

DOI: https://doi.org/10.4046/trd.2022.0149

Original Article

Lung Cancer

Immune Regulatory Function of Cancer- Associated Fibroblasts in Non-small Cell Lung Cancer

Hyewon Lee, Mina Hwang, Seonae Jang, et al.

Tuberc Respir Dis. 2023;86(4):304-318. Published online June 22, 2023

Background: Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment and significantly contribute to immune evasion. We investigated the effects of CAFs on the immune function of CD4+ and CD8+ T cells in non-small cell lung cancer (NSCLC). Methods: We isolated CAFs and normal fibroblasts (NFs) from tumors and normal lung tissues of NSCLC patients, respectively. CAFs were co-cultured with...

DOI: https://doi.org/10.4046/trd.2022.0129

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