INH-PAS in the Trestment of Amburatory Cases of Pulmonary Tuberculosis (T.I.D Regimen vs B.I.D. Regimen)

Lee, Hyo Keun; Ham, Sung Sook; Kim, Hyung Duk; Koh, Woon Hee

doi:1963.0.16.29

Tuberc Respir Dis > Issue 16; 1963 > Article

Tuberculosis and Respiratory Diseases 1963;16:29-31.
DOI: https://doi.org/10.4046/trd.1963.16.1.29 Published online December 1, 1963.

INH-PAS in the Trestment of Amburatory Cases of Pulmonary Tuberculosis (T.I.D Regimen vs B.I.D. Regimen)

Hyo Keun Lee, Sung Sook Ham, Hyung Duk Kim, Woon Hee Koh

Department of Chest Clinic, Yonsei University, College of Medicine, Seoul, Korea

Abstract

It is estimated that there are approximately 800,000 patients with pulmonary tuberculosis and less than 4,000 sanatorium beds in Korea. Therefore, majority of patients remain at home and get chemotherapy on an ambulatory base. The conventional chemotherapy, INH(300mg)-PAS(10gm) in three divided doses, is not convenient for ambulatory cases particularly, those who have job. They do not like to take drugs in public and usually omit the second dose of drugs. Recently, some observations indicated that the better therapeutic results were associated with the higher peak serum concentrations rather than low sustained levels were maintained. It is also indicated that 6-10gm of daily PAS would be sufficient when combined with INH. The purpose of this study is to compare the clinical efficacies between the cases treated with INH(300mg)-PAS(10gm) in three divided doses and cases treated with INH(400mg)-PAS(8gm) in two divided doses.