Idiopathic Pulmonary Fibrosis: Correlations between Bronchoalveolar Cellular Constituents and the Pathologic, Physiologic and Radiographic Features and Response to Treatment

Cho, S. H.; Lee, S. D.; Kwon, O. J.; Lee, C. T.; Chung, H. S.; Han, S. K.; Shim, Y. S.; Kim, K. Y.; Han, Y. C.; Ham, E. K.

doi:1989.36.4.310

Tuberc Respir Dis > Volume 36(4); 1989 > Article

Original Article

Tuberculosis and Respiratory Diseases 1989;36(4):310-319.
DOI: https://doi.org/10.4046/trd.1989.36.4.310 Published online December 1, 1989.

Idiopathic Pulmonary Fibrosis: Correlations between Bronchoalveolar Cellular Constituents and the Pathologic, Physiologic and Radiographic Features and Response to Treatment

S. H. Cho¹, S. D. Lee¹, O. J. Kwon¹, C. T. Lee¹, H. S. Chung¹, S. K. Han¹, Y. S. Shim¹, K. Y. Kim¹, Y. C. Han¹, E. K. Ham²

¹Department of Internal Medicine & Tuberculosis Research Institute, College of Medicine, Seoul National University, Seoul, Korea
²Department of Pathology, College of Medicine, Seoul National University, Seoul, Korea

특발성 폐섬유화증 환자에서 기관지폐포세척액 소견과 생리-방사선-조직학적 진행도와의 상관관계 및 스테로이드 치료에 대한 예후인자와 구성세포 변화에 관한 연구

조상헌¹, 이상도¹, 권오정¹, 이춘택¹, 정희순¹, 한성구¹, 심영수¹, 김건열¹, 한용철¹, 함의근²

Abstract

Analysis of bronchoalveolar lavage cellular constituents has been recommended as a useful method for determination of immune and inflammatory cellular population. prognosis and activity of idiopathic pulmonary fibrosis (I PF). But the clinical relevance of the determination of cellular populations of bronchoalveolar lavage fluid (BALF) from idiopathic pulmonary fibrosis remains controversial. We examined bronchoalveolar lavage profiles and correlations with both the pathologic. physiologic and radiologic severity and the responsiveness to corticosteroid treatment from 21 patients with idiopathic pulmonary fibrosis, including 5 patients associated with connective tissue disease. The BALF cellular constituents. physiologic impairments and the histologic abnormalities were identical between PF and IPF associated with connective tissue disease. In patients with IPF, BALF total cell counts and the proportions of Iymphocyte, neutrophil, and eosinophil were increased. And the BALF cellular constituents did not correlated significantly with physiologic, radiologic and pathologic severity. The initial BALF Iymphocytosis and lower eosinophil count was associated with responsiveness to corticosteroid treatment. We suggest that even in the case of advanced pulmonary destruction with BALF lymphocytosis, there is considerablely reversible component with corticosteroid treatment. In conclusion, cellular constituents in BALF was not consistently related to pathologic, radiologic and physiologic severity. And BALF lymphocytosis would be regarded as a indication of better prognosis with corticosteroid treatment.