Expression of intercelluar adhesion molecule-1 in human idiopathic pulmonary fibrosis.

Park, Sung Soo; Shin, Dong Ho; Kim, Tae Wha; Lee, Dong Hoo; Lee, Jung Hee; Lee, Jung Dal

doi:1993.40.2.185

Tuberc Respir Dis > Volume 40(2); 1993 > Article

Original Article

Tuberculosis and Respiratory Diseases 1993;40(2):185-191.
DOI: https://doi.org/10.4046/trd.1993.40.2.185 Published online April 1, 1993.

Expression of intercelluar adhesion molecule-1 in human idiopathic pulmonary fibrosis.

Sung Soo Park¹, Dong Ho Shin¹, Tae Wha Kim¹, Dong Hoo Lee¹, Jung Hee Lee¹, Jung Dal Lee²

¹Department of Internal Medicine, Hanyang University Hospital, Seoul, Korea
²Department of Pathology, Hanyang University Hospital, Seoul, Korea

Abstract

Background
intercellular adhesion molecule-l (ICAM-ll is a 90 kD surface glycoprotein, associated with αLβ2 and αMβ2 subunit of integrins, that serve as cell-cell and cell -substratum adhesion molecules and help regulate cellular morphology, differentiation, and proliferation. The adhesion molecules likely play important roles in maintaining the normal structure and function of the lung ICAM-l system among many cell adhesion molecules is importantly issuing in the pathogenesis of idiopathic pulmonary fibrosis.
Methods
By using IgG₁ monoclonal antibody for ICAM-l, we investigated immunohistochemically the expression of ICAM-l in the formalin-fixed, paraffin-embedded tissue sections of the 3 normal cases and 6 pieces of tissues taken 3 cases with idiopathic pulmonary fibrosis.
Results
ln the 3 normal cases, the expressions of lCAM-l were not discernible. Up-regulation of the ICAM -l expression was showed in the interstitia l fibroblast cells of a lveolar septa in 5 pieces and proliferated alveolar pneumocytes in 1 piece among 6 pieces of tissues taken 3 cases with idiopathic pulmonary fibrosis.
Conclusion
lt was concluded from these findings that up-regulation of the ICAM-l expression may be related to pathogenesis of idiopathic pulmonary fibrosis.

Key Words: Expression, lntercellular adhesion molecule-l, Idiopathic pulmonary fibrosis