Primary Signet Ring Cell Carcinoma of the Lung: A Case Report.

Cho, Joo Yeon; Lee, Hyun Kyung; Lee, Sung Soon; Lee, Young Min; Jin, Jae Yong; Lee, Hyuk Pyo; Kim, Joo In; Choi, Soo Jeon; Kang, Yun Kyung; Ro, Jae Yoon; Yum, Ho Kee

doi:2004.57.5.461

Tuberc Respir Dis > Volume 57(5); 2004 > Article

Case Report

Tuberculosis and Respiratory Diseases 2004;57(5):461-464.
DOI: https://doi.org/10.4046/trd.2004.57.5.461 Published online November 1, 2004.

Primary Signet Ring Cell Carcinoma of the Lung: A Case Report.

Joo Yeon Cho, Hyun Kyung Lee, Sung Soon Lee, Young Min Lee, Jae Yong Jin, Hyuk Pyo Lee, Joo In Kim, Soo Jeon Choi, Yun Kyung Kang, Jae Yoon Ro, Ho Kee Yum

¹Department of Internal Medicine, Inje University, College of Medicine, Korea. pulho@korea.com
²Department of Pathology, Inje University, College of Medicine, Korea.
³Department of Pathology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea.

Abstract

Signet ring cell carcinoma (SRCC) of the lung is a rare variant of pulmonary adenocarcinoma. Because the majority of SRCCs seen in the lung are metastatic tumors from stomach, colon, or breast, the differentiation of primary SRCC from metastatic SRCC is important but may be problematic. Recently, immunohistochemical studies are known to be valuable in determining primary sites of SRCC. Herein, we presented a case of primary signet ring cell carcinoma of the lung in a 67-year-old man. Even though radiographic findings of our case were more suggestive of metastatic orgin of SRCC in the lung, we could finally conclude that lung was the primary site of SRCC in this case with the help of immunohistochemical studies (TTF-1 and CK7 positive and CK 20 negative) and other diagnostic work up.

Key Words: signet ring cell carcinoma, lung, TTF-1