| Matrix Metalloproteinase-1 and Tissue Inhibitor of Metalloproteinase-1 levels in Exudative Pleural Effusions. |
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Jae Hwa Cho, Jeong Hyeon Nam, Kyum Ho Lee, Byeong Kab Yoon, Jeong Sun Ryu, Sung Min Kwak, Hong Lyeol Lee |
1Department of Internal Medicine, College of Medicine, Inha University, Incheon, Republic of Korea. jaehwa.cho@inha.ac.kr
2Department of Clinical Pathology, College of Medicine, Inha University, Incheon, Republic of Korea. |
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| Abstract |
BACKGROUND
The balances of the proteinases and antiproteinases system have been implicated in the pathogenesis of various exudative pleural effusions. The aim of this study was to examine the matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) levels in exudative pleural effusions. METHODS: The study included 33 tuberculous effusions, 17 malignant, and 5 transudates. The pleural levels of MMP-1 and TIMP-1 were determined using a commercially available ELISA assay. RESULTS: The group of tuberculous effusions showed higher pleural MMP-1 levels than the malignant and transudates. The pleural TIMP-1 levels of the tuberculous and malignant effusions were higher than the transudates. CONCLUSION: Elevated pleural MMP-1 and TIMP-1 levels were found in tuberculous effusions. |
| Key Words:
Matrix metalloproteinase, Pleural effusion, Tissue inhibitor of metalloproteinase |
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