A Case of Bronchiolitis Obliterans Organizing Pneumonia Following CHOP Chemotherapy and Filgrastim Use in a Patient with Diffuse Large B-cell Lymphoma.

Chung, Wou Young; Byun, Min Kwang; Lee, Jin Hyoung; Hahn, Chang Hoon; Kang, Shin Myung; Kim, Jin Seok; Cho, San Ho; Kim, Young Sam; Kim, Se Kyu; Chang, Joon; Kim, Sung Kyu; Park, Moo Suk

doi:2005.59.5.561

Tuberc Respir Dis > Volume 59(5); 2005 > Article

Case Report

Tuberculosis and Respiratory Diseases 2005;59(5):561-565.
DOI: https://doi.org/10.4046/trd.2005.59.5.561 Published online November 1, 2005.

A Case of Bronchiolitis Obliterans Organizing Pneumonia Following CHOP Chemotherapy and Filgrastim Use in a Patient with Diffuse Large B-cell Lymphoma.

Wou Young Chung, Min Kwang Byun, Jin Hyoung Lee, Chang Hoon Hahn, Shin Myung Kang, Jin Seok Kim, San Ho Cho, Young Sam Kim, Se Kyu Kim, Joon Chang, Sung Kyu Kim, Moo Suk Park

¹Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. ms70l@yumc.yonsei.ac.kr
²Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
³The Institute of Chest Diseases, Yonsei University College of Medicine, Seoul, Korea.
⁴Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
⁵Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul, Korea.

Abstract

Bronchiolitis obliterans organizing pneumonia (BOOP) is often diagnosed in patients with pneumonia who respond poorly to antibiotics. BOOP is often idiopathic, and the etiology of the remaining cases has been attributed to a wide range of agents or medical conditions. When a patient develops the clinical symptoms characteristic of BOOP, the medical team must endeavor to determine the etiology of this disease because it can be treated with glucocorticoid and avoidance of the causative agent. In particular, if BOOP is diagnosed during or after chemotherapy for a malignancy, the possible culprit agent can be the anti cancer drugs but other drugs used for supportive care must be also be considered. We report a case of BOOP that arose after CHOP chemotherapy and a filgrastim injection in a patient with a diffuse large B-cell lymphoma.

Key Words: Bronchiolitis obliterans organizing pneumonia, Diffuse large B-cell lymphoma, CHOP, Filgrastim