| Cognitive Dysfunction in non-hypoxemic COPD Patients. |
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Woo Jin Kim, Seon Sook Han, Myoung Ok Park, Seung Joon Lee, Seong Jae Kim, Jung Hie Lee |
1Department of Internal Medicine, College of Medicine, Kangwon National University, Chuncheon, Korea.
2Department of Psychiatry, College of Medicine, Kangwon National University, Chuncheon, Korea. jhielee@kangwon.ac.kr |
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| Abstract |
BACKGROUND
The cognitive function is impaired in patients with hypoxemic chronic obstructive pulmonary disease (COPD). However, there are conflicting results regarding the cognitive function in patients with non-hypoxemic COPD. COPD patients also have sleep disorders. This study examined the cognitive function in non-hypoxemic COPD patients, and nocturnal sleep was assessed in COPD patients with a cognitive dysfunction. METHODS: Twenty-eight COPD patients (mean age, 70.7 years) with an oxygen saturation > 90%, and 33 healthy control subjects (mean age, 69.5 years) who had visited for a routine check-up were selected. The neurocognitive tests were performed using the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K) Neuropsychological Battery. RESULTS: The scores of the word list recall test (p=0.03) and the word list recognition test (p=0.006) in the COPD group were significantly lower than those in the control group. Nine patients showed a significantly impaired cognitive function. Seven of these underwent polysomnography, which revealed apnea-hypopnea indices > or = five per hour in five patients. The median oxygen desaturation index and median limb movement index were 3.6/h and 38.6/h, respectively. CONCLUSION: These results suggest that the verbal memory function is impaired in non-hypoxemic COPD patients. Six out of seven COPD patients with an impaired cognitive function had sleep disorders of sleep apnea and/or periodic limb movements during sleep. |
| Key Words:
Chronic obstructive pulmonary disease, Cognitive function, Sleep disorders |
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